Views of leadership that focus on the traits and behaviors of the leader are commonly used to develop training programs. Although these leadership training programs have some application, they suffer from several problems. First, there is no reasonable agreement on what traits or behaviors are leadership traits or behaviors. Second, there is no way to differentiate what makes a good leader from what makes an effective manager or an effective person. And third, people who emerge from these training programs rarely become what anyone might define as good leaders. A view of leadership as a community development process is explored as an alternative to traditional leadership approaches, and its implications for training and education are discussed.
Executive SummaryThe industrial view of leadership is inadequate for educational purposes because it does not address the nature of the complex social relationships among people who practice leadership, nor does it accurately accommodate their purposes, motives, and intentions. A distinction among the practices of training, development, and education provides a means to explore an understanding of these complex social relationships relative to the preparation of leaders for the future. The content of leadership education in the future will cover three broad categories: the evolution of social change and development, the processes that influence social development, and the dynamics of human nature in change processes. Leadership education is aimed at producing citizens for a democratic society.
Abstract. In recent years mechanical systems have been developed that more closely mimic the full dynamic, physical and biochemical complexity of the GI Tract. The development of these complex systems raises the possibility that they could be used to support formulation development of poorly soluble compounds and importantly may be able to replace clinical BE studies in certain circumstances. The ability of the TNO Simulated Gastro-Intestinal Tract Model 1 (TIM-1) Dynamic Artificial Gastrointestinal System in the 'lipid membrane' configuration to support the development of Biopharmaceutics Classification System Class 2 compounds was investigated by assessing the performance of various AZD8055 drug forms and formulations in the TIM-1 system under standard fasting and achlorhydric physiological conditions. The performance data were compared with exposure data from the phase 1 clinical study. Analysis of the AZD8055 plasma concentrations after tablet administration supported the conclusions drawn from the TIM-1 experiments and confirmed that these complex systems can effectively support the product development of poorly soluble drugs. Particularly, the TIM-1 system was able to show that AZD8055 exposure would increase in an approximately dose proportional manner and not be limited by the solubility or dissolution. Additionally, the investigations also showed that the exposure produced by a solution and a tablet would be the same. Specific instances when the TIM-1 system may not be predictive of clinical product performance have also been identified.
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