In patients with dysplastic Barrett's esophagus, radiofrequency ablation was associated with a high rate of complete eradication of both dysplasia and intestinal metaplasia and a reduced risk of disease progression. (ClinicalTrials.gov number, NCT00282672.)

Low-dose aspirin has a moderate chemopreventive effect on adenomas in the large bowel.

OLIC ACID AND ITS DERIVATIVES (folate) are essential nutrients in humans and play an important role in nucleotide synthesis and methylation reactions. 1 Folate deficiency leads to macrocytic anemia, and abundant evidence indicates that even in well-nourished western populations, folate supplementation reduces the risk of neural tube defects. 2 Considerable epidemiological evidence suggests that a low-folate diet is associated with an increased risk of colorectal neoplasia, 3-5 particularly in concert with alcohol, which can antagonize the metabolism of folate. 6,7 Much animal data support an antineoplastic effect of folate. However, in some animal studies, folate deficiency protects against, and supplementation increases, experimental carcinogenesis. 3 For editorial comment see p 2408.

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