The effects of topical fluocinolone therapy on the lesions of mycosis fungoides were evaluated in 6 patients. Concentrations of fluocinolone 0.01 to 0.2% beneath occlusive plastic film were used. Pre‐ and post‐treatment histological studies were carried out. Treatment was effective in modifying lesions both clinically and microscopically. The degree of improvement appeared proportionately related to the concentration used. No serious side effects were observed. Improvement was noted for as long as 9 months when therapy was continued.

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