Sesame seed (Sesamum indicum L) oil is an excellent source of unsaturated fatty acids and secondary metabolites. Most commonly used in Eastern countries, easily available and cheap source of essential nutrients. Objective: To identify scientific evidence regarding the hypolipidemic effect of sesame seed oil and its derivatives. Elevated levels of plasma lipids and cholesterol is known as hyperlipidemia, increased lipids levels are directly associated with vascular and metabolic disorders. Hyperlipidemia is the most common risk factor of cardiovascular diseases. Sesame seed oil is loaded in vitamin E, sesamin, sesamolin, sesamol, lignans, and phytoestrogen, these constituents have the potential to reduce hyperlipidemia, hypercholesterolemia, and elevated triglycerides levels.  They also act as antioxidants to prevent lipid peroxidation and oxidative stress. The mechanism behind the hypolipidemic effect of sesame seed oil is its ability to increase superoxide dismutase SOD and glutathione peroxidase (antioxidants), reduction in triglycerides, and Malondialdehyde (MDA) concentration. MDA is the end product of lipid peroxidation and triggers lipid accumulation in blood. It has been studied that Sesaminol diglucoside helps to reduce white fat deposition by increasing the conversion of fat into brown fat. Conclusions: Results suggest that sesame seed oil is highly effective to manage hyperlipidemia and dyslipidemia due to its lipid ameliorating and anti-oxidative effect

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Hyperlipidaemia is characterized by abnormally elevated levels of body’s plasma cholesterol and triacylglycerol. Objective: To find out the proximate composition of Nigella sativa L. and its hypolipidemic effect on blood lipid profile among hyperlipidaemic women. Methods: To determine the proximate composition of Nigella sativa seed the kjeldhah method, soxhlet extraction using petroleum ether, and AOAC procedure were used. For the identification of hypolipidemic impact, a total of 64 women with mild to moderate hyperlipidaemia, aged between 25-35 years were selected for the 8 weeks of study. The sample was selected from the University of Lahore Teaching Hospital, Lahore. After removing physical contaminants like dirt, dust, and other foreign grains black seeds were air dried. After drying, seeds were grounded into fine powder by using commercial blender. Each capsule was prepared with 500mg powder of N. sativa, and was transferred in air tight jars. After screening the participants of experimental group, they were advised to use 2 capsules of N. sativa supplement before breakfast and two capsules in the afternoon prior to their meal for 8 weeks. Participants were also advised to follow the given 7-day diet plan for 8 weeks. The anthropometric measurements, biochemical evaluation (lipid profile), and dietary intake data were collected. Results: The mean age group of Hyperlipidaemic patients enrolled in study was 32.5±0.34 years. There was a significant reduction in Low Density Lipoprotein (LDL), total cholesterol level, and triglyceride levels with p-value less than 0.05. High density lipoprotein levels were also improved from 49.5±8.38mg/dl to 51.81±10.21mg/dl. Conclusion: The study concluded that Nigella sativa L. seed powder supplementation showed a significant improvement in lipid profile of hyperlipidaemia patients.  The study found an increase in high density lipoprotein among patients.

Objective: To find out the proximate composition of Nigella sativa L. and its hypolipidemic effect on blood lipid profile among hyperlipidemic women. Methodology: To determine the proximate composition of nigella sativa seed the kjeldhah method, soxhlet extraction using petroleum ether and AOAC procedure were used. To determine hypolipidemic impact a total of 64 mild to moderate hyperlipidemic women aged 25-35 years were selected for the 8 weeks of study. The sample was selected from the university of Lahore teaching hospital, Lahore. After removing physical contaminants like dirt, dust and foreign grains black seeds were air drayed. After drying seeds were ground into fine powder by using commercial blender. Each capsule was prepare containing 500 mg powder of N. Sativa, and transfer them in air tight jars. After screening the participants of experimental group were advised to use 2 capsule Nigella sativa supplement before breakfast and two capsules in the afternoon prior to their meal for 8 weeks .Participants were also be advised to follow the given 7-day diet plan for 8 weeks. The anthropometric measurements, biochemical evaluation (lipid profile) and dietary intake data were collected. Results: The mean age group of Hyperlipidemic patients enrolled in study was 32.5 ± 0.34 years. There was a significant reduction in Low density lipoprotein (LDL) Total Cholesterol levels and Triglycerides levels with p-value less than 0.05. High density lipoprotein levels were also improved from 49.5±8.38mg/dl to 51.81±10.21 mg/dl. Conclusion: The study concluded that Nigella sativa L. seed powder supplementation showed a significant improvement in lipid profile of hyperlipidemic patients. The study found an increase in high density lipoprotein among patients. Keywords: Nigella sativa L. seed powder, Black cumin, Blood Lipid profile, Hyperlipidemia, Hypolipidemia, Lipid ameliorating effect, Proximate analysis

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