We describe here a rapid and straightforward solvent-free method to access phenylthiazolo[5,4-b]pyridines using a Nd-YAG laser NANO-NY81-10 (λ = 355 nm, 10 Hz pulse frequency; 8 ns pulse duration).

A practical microwave-assisted CH activation for the preparation of several phenoxythieno[3,2-b]pyridines is reported here. This new strategy is an efficient alternative to the conventional methods currently used. The optimized conditions can also be applied to a one-pot approach.