These results suggested that mangiferin had better protective effect against DOX-induced cardiac toxicity in comparison with SYL and VitE, thus besides the antioxidant activity, different mechanism may be involved in the action of mangiferin and need to be clarified in the future studies.

This study was conducted to elucidate the intestinal dysmotility during coccidiosis. C57BL/6 male mice at seven weeks of age were inoculated with Eimeria pragensis sporulated oocysts (100 to 1,000 oocysts). The intestinal motility was evaluated by observing discharging time of barium sulfate (Ba 2 SO 4 ) after oral administration (WITT: the whole intestinal transit time). The exact location of the dysmotility was analyzed by intermittent barium gastrography. Upper intestinal dysmotility was evaluated by charcoal propulsion study. Additionally, the occurrence of dysmotility was observed at different post-infection times (4, 7, and 14 days post-infection (d.p.i.)) and in infection-dose dependent manner (100, 300, and 1,000 oocysts). As the E. pragensis infected mice had significantly lower feed intake compared to the control group, we designed a feed apprehension study to evaluate the effect of low feed intake on the intestinal dysmotility. The WITT of infected mice at 7 d.p.i. was significantly longer (6 hr) than the uninfected mice (2.5 hr). Intestinal dysmotility was observed in the small intestine, caecum, and colorectum in the infected mice. Charcoal propulsion was slower in infected group (reaching to 40.4% of the whole small intestine) compared to control group (68.0%). The dysmotility was observed at the beginning of the patent period (7 d.p.i.) and subsided as the patency ended (14 d.p.i.). Mice with lower feed intake appeared to have similar intestinal motility as control mice. In summary, this study revealed the evidence of intestinal hypomotility during E. pragensis infection.

Cryptorchidism is defined as the failure of the testis to descend into the scrotal position. Bulls with cryptorchidism have problems in both meat quality and husbandry management; thus, it is greatly important to accurately identify the retained testis and remove it during the early stage. Abdominal computed tomography (CT) was performed under general anesthesia in 34 bulls aged 3-9 months with cryptorchidism. All bulls underwent laparoscopic or incision approach for cryptorchidectomy, and 40 testes wer e dissected. The detection rates of retained testes were 64.5% in the abdominal cavity and 100% in the subcutaneous inguinal region, and the total detection rate was 72.5%. Furthermore, all cases in this study were suspected to have intra-abdominal cryptorchidism in primary care, but CT revealed that 22.5% of cases had cryptorchidism in the subcutaneous inguinal region. The CT value (mean ± standard deviation) of the retained testes was 20.96 ± 7.41 Hounsfield Unit, and the CT value and size of th e retained testes showed a positive weak correlation with bovine age. Therefore, there is the demerit that general anesthesia and a huge device are necessary; nevertheless, CT is suggested to be useful in identifying the location of retained testes and selecting an appropriate surgical approach in bulls with cryptorchidism. Moreover, CT findings suggested that the maturation of the retained testes might depend not on the descendin g process but on age.

Sepsis merupakan respon sistemik yang disebabkan oleh infeksi. Mortalitas sepsis dapat mencapai 30% meskipun telah dilakukan perawatan intensif. Renjatan sepsis adalah sepsis yang disertai dengan gangguan pada organ kardiovaskular dan respirasi. Penelitian ini bertujuan mengevaluasi parameter gas darah setelah induksi sepsis dan resusitasi cairan. Sebanyak 10 ekor anak babi dengan berat badan 10-13 kg dan umur 2-3 bulan dibagi menjadi dua kelompok perlakuan. Kelompok pertama diresusitasikan dengan cairan koloid modifikasi gelatin 4% (MFG 4%) sedangkan kelompok dua diresusitasikan dengan cairan kristaloid ringer asetat malat (RAM). Lipopolisakarida E. coli sebanyak 50 ug/kg berat badan diberikan dengan rute intravena untuk menginduksi terjadinya sepsis. Induksi sepsis menyebabkan penurunan pH dan PaO₂, serta peningkatan PaCO₂ dan laktat secara nyata (p<0.05). Resusitasi cairan dilakukan setelah renjatan sepsis. Resusitasi dengan cairan koloid dapat mengembalikan nilai PaCO₂ dan PaO₂ mendekati normal, serta menekan edema paru. Resusitasi dengan cairan koloid dinilai lebih baik karena dapat meminimalisir kerusakan yang terjadi akibat renjatan sepsis.