Amavata is the most crippling of the joint diseases, found globally in all climates and ethnic groups. It is a disease instigated due to the vitiation or worsening of Vayu linked with Ama (Undigested food). Vitiated Vayu mingles the Ama all over the body through Dhamanies (Arteries & Veins), takes lodging in the Shleshma Sthana (small and big joints) & harvest symptoms such as stiffness, swelling and tenderness thus assembly a person lame. The symptoms of Amavata revealed in Ayurveda are found slightly undistinguishable to Rheumatism, which embrace Rheumatoid arthritis & Rheumatic Fever. Due to extensive gamut of disease, abundant more prevalence in the civilisation and deficiency of effective medicine, the disease has been selected for the literary Survey. Acharya Govinddas Sen has mentioned numerous formulations acting on Aamvata (Rheumatoid Arthritis) in his book Bhaishajya Ratnavali. The present study is designed to screen the formulations with Ama-vatahara (Anti-Rheumatoid Arthritis) property. Out of 3456 formulations mentioned in Bhaishajya Ratnavali, 151 are found described for the treatment of Rheumatoid arthritis throughout the text which includes herbal, mineral and animal origin drug formulations.

Standard operating procedure for pharmaceutical preparation of Devdarvadyarishta has been developed in the present research work. A pilot scale study having 3 batches was carried out initially to find out the best possible fermenting vessel among glass jar, porcelain jar and stainless steel vessel and also to investigate for any possible hurdle related with fermentation process as honey and not jaggery is used as sweetening agent in this formulation. Three samples of Devdarvadyarishta as per conventional method were prepared in accordance with Bhaishjya Ratnavali and process for standard of Devdarvadyarishta was set in as a Quality specification for the same. Porcelain jar was found to be the best as per the results of pilot study as evident by alcohol content of 5.73%, 6.25% and 6.10% respectively in glass jar, porcelain jar and stainless steel vessel, the reaction being completed in between 38-47 days.  Approximate duration of Kwatha formation in all the batches was 9 hours with peak temperature during boiling being maintained at 920C. In all the three batches, fermentation started on 7th day, 7th day and 9th day, total duration of fermentation was 72 days, 70 days and 75 days, with % loss of 15.78%, 17.76% and 19.07% respectively. Mean % loss observed during preparation was 17.53%.

Ayurveda with safe and effective goodness has been pouring its valuable treasures to mankind since time unknown. Guggulu preparations are supposed to be one among the finest shaman aushadha in the Vata vyadhis. Literature enlists a number of such guggulu preparations in the management of Vatarakta. In the present study literature regarding Gokshuradi Guggulu quoted in Sharangadhar Samhita for the management of Vatarakta is expounded with all possible details. Individual drugs of the chosen formulation is expanded with respect to their synonyms, botanical details including Latin name, family, botanical description and parts used, Rasa Panchaka, chemical constituents and modern research references related to Gout that can prove beneficial for mankind.

Knowledge of medical sciences and arts only is not sufficient to qualify a medical practitioner but he is expected to be acquainted with a number of other sciences which are likely to bear some relation to life. A full conception of science will never be attained by the knowledge of only a part of it. If a man be well read in Charak but ignorant of even the name of diseases described in Sushrat and other works or if he be not wanting in practical methods but wholly ignorant of Charak what can such a poorly equipped man do to relieve the ailment of patients. Three methods to obtain the knowledge are Adhyayana (Study), Adhyapana (Teaching) and Sambhasha (participating in debates), from which the last method 'Tadvidya Sambhasha' (debate between experts of same field) is being discussed in detail. In the ancient period the method is known as Sambhasha, as the time changed from ancient to modern era it takes the form of Symposium. The methodologies and purposes of both are similar along with the discussion methods while following the rules and regulations with the introduction of new techniques and advancement of technology. Today many milestones achieved in the field of Ayurveda by organizing the committees like Chopra and Pandit committee to debate for the promotion of education and practice of Ayurveda in country.

Gout is condition in which person become immobile and inactive due to joint pains and swelling. Gout occurs, when urate crystal deposition of in the joints. Vatarakta is considered as a vata pradhana vyadhi and rakta dushti. Gokshuradi Guggulu is having vatahara and raktashodhak properties. Guduchi kwatha selected as anupana because of its Rasayana, Vatashamaka, Balya, vedana sthapana and Ama pachana properties will help to disrupt the Samprapti vighatana of vatarakta. The objectives of the study were to evaluate the effect of Gokshuradi Guggulu with Anupanabheda in the management of Vatarakta and to compare the result of both groups. This study was randomized, parallel comparative clinical trial of two groups each of 20 patients. From OPD of DBACH Mandigobindgarh; 40 patients of vatarakta taken which were randomly divided into two groups. Group A, 20 patients for 60 days received Gokshuradi Guggulu 1 gm. BD with lukewarm water and Group B,20 patients received Gokshuradi Guggulu 1gm BD with Guduchi Kwatha for 60 days. In Group A, among 20 patient’s 55% patients showed moderate response and 45% patients showed mild response. In Group B among 20 patients, 95 % patients showed moderate response and 5 % patients showed mild response. Both shows statistically highly significant results in both subjective and objective except erythema & discoloration. Treatment modality in Group B (i.e. Gokshuradi Guggulu with Guduchi Kwatha) is effective in comparison of treatment modality in Group A (i.e. Gokshuradi Guggulu with lukewarm water).