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Concepts emerging from experimental manipulations of neurobiological systems in vivo and in vitro may provide explanations for some clinical observations following adrenal medulla autografting in patients with Parkinson's disease. These concepts are reviewed, and a proposed mechanism of action of adrenal autografts in Parkinson's disease is advanced. RESUME: Des autogreffes medullosurrenales dans la maladie de Parkinson: un mecanisme propose. Les concepts provenants des manipulations experimentales de systemes neurologiques in vivo et in vitro peuvent expliquer quelques-unes des observations cliniques a la suite des greffes medullosurrenales chez des patients atteints de la maladie de Parkinson. Nous avons fait la critique de ces concepts et avons propose un possible mecanisme d'action.