Research on local herbs that have the effect of increasing breast milk production isneeded to help mothers with insufficient breastmilk. This research was conducted to determinethe effect of torbangun (Coleus amboinicus L) leaf powder in increasing prolactin inbreastfeeding Wistar rats and the bodyweight of the litters. Thirty breastfeeding Wistar rats weredivided into 5 groups with 5 litters each. The treatments given were 108 mg, 216 mg, and 432 mgtorbangun leaf powder (TLP), with domperidone as the positive control, and CMC 10% as thenegative control. The treatment was given 3 times/day for 14 days. Tukey's HSD means testshowed a significant difference in prolactin levels between the negative control (NC), TLP1, andTLP2 groups and the TLP3 and positive control (PC) groups with all of them having p = 0.000.There was no difference in the increase in body weight of litters between treatment groups (p =0.866). In conclusion, torbangun leaves increase the prolactin levels in breastfeeding rats buthave no difference in the increase in body weight of litters between treatment groups. Keywords: torbangun leaves; prolactin; bodyweight; breastfeeding

This study was an observational analytic study conducted in the Hemodialysis unit of Zainal Abidin Hospital (RSUDZA), Banda Aceh, Indonesia. Data collection was carried out by taking secondary data from CKD patient visits in January-December 2019. The study population was all CKD patients in the registry of 2019 in the hospital, with a total of 406 patients enrolled. The highest unit cost of care based on real costs was the cost of surgical procedures, and the cost difference between INA-CBG’s and hospital tariffs in the treatment of patients with CKD is significantly different (p-value = 0.014, with gap difference of IDR 2,146,086). It is suggested  an urgent evaluation and scrutinization for the management of CKD patients with hemodialysis to prevent the different treatment costs in the service

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