Occupational stress is recognized as a global health issue that affects all professions, no other profession in the health field i.e. medical record registration section. RSUP Dr. Sardjito Yogyakarta has a total data visit annually on an outpatient registration, which is in 2018 as much as 469813 and in 2019 as many as 518806. The number of visits explained at least the registration staff should serve 200-300 patients every day. Known errors that occur in SIMETRISS also harm the officer because inevitably officers should double job. The Stress of work felt by the officers of the list is often felt muscle tension, feel tense, fast angry, feel anxious, and difficult to concentrate in the work. Stressful work if not resolved will have an impact on activities in the scope or out of work. The research aims to figure out the work stress overview of the registration officers in RSUP Dr. Sardjito Yogyakarta. The collection methods used are interviews. The analysis of the data used in this study is qualitative. The results of the study showed work stress experienced by outpatient registration officers, that is caused by a physical work environment that is less comfortable to cause a lack of concentration by the officers and causes the performance of officers to decline, the conflict between family demands and the demands of agencies such as the use of less time breaks and the presence of a sustained shift, performance demands are done quickly and precisely however support facilities, namely Simetriss still error also raises pressure for the work RSUP Dr. Sardjito Yogyakarta has reduced some problems by conducting effective consultation on outpatient registration officers.