A series of [1,2,4]triazolo[3,4-b][1,3,4]thiadiazoles (7-15) and the thiadiazine analogues 16-18 have been synthesized under microwave irradiation (MWI). All synthesized compounds are evaluated for their antiviral activity against the replication of HIV-1 and HIV-2 activity in MT-4. However, compounds 12 and 18 showed EC(50) = 2.11 and 1.97 mug/mL. The results suggest that these compounds can be considered as a new lead in the development of antiviral agents. Compounds 4-18 were tested in vitro against a panel of tumor cell lines. All compounds are inactive against all the tumor sub-lines, except 10 which exhibited activity against CD4(+) human acute T-lymphoblastic leukaemia of CC(50) = 64 muM.

In the surviving fragments of his treatise On Heraclea the historian Memnon assigns a central role to the exiles from Heraclea. As opponents of tyranny, they represented a destabilising element, a constant danger to the survival of the Clearchid regime. This article explores the events that led to the banishment of the exiles, reconstructs the politics of expulsion implemented by the tyrants, and clarifies the status of the exiles and their political orientation in the light of Memnon’s frequent juxtaposition of the exiles’ demand to return to their homeland and the restoration of democracy.

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In vitro anti-HIV and Antitumor Activity of New 3,6-Disubstituted [1,2,4]Triazolo[3,4-b][1,3,4]thiadiazoles and Thiadiazine Analogues. -12 Title compounds of type (V), (VII), and (IX) are prepared and evaluated for their antiviral activities against the replication of HIV-1 and HIV-2 activity in MT-4. Only (Vc) exhibits activity against CD4 + human acute T-lymphoblastic leukaemia. -(AL-SOUD, Y. A.; AL-MASOUDI*, N. A.; LODDO, R.; LA COLLA, P.; Arch.