Nurses are one of the health workers who provide primary health services. Apart from being a large number in hospitals, its presence and role are strongly associated with patient safety and quality of care. Nurse job satisfaction has become one of the benchmarks for the quality of patient care. Research on the effects of professionalism and structural empowerment simultaneously on job satisfaction has never been done before. This study examines the impact of professionalism and structural empowerment on job satisfaction among inpatient nurses. This study is in the form of a cross-sectional survey. As many as 129 nurses from Bengkayang Regional Hospital and Landak Regional Hospital participated in this study. To collect data, Hall Professionalism Scale, Conditions for Work Effectiveness Questionnaire II, and Job Satisfaction Survey were delivered to respondents. Data were then analyzed using multiple linear regression. According to analysis, there is a significant effect of professionalism and structural empowerment on the job satisfaction of inpatient nurses