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Force degradation studies of drug substance give perceptive knowledge about the intrinsic stability of the molecule as well as possible degradants which formed during the shelf life of drug and thus, aid within the successive development of its stable formulation. A number of analytical methods with hyphenated techniques are required for the identification, determination and characterization of degraded product and impurities produce during different conditions of stress studies; Chromatographic methodology play a vital role in the field of impurity and degradation profiling .This review summarizes the current regulatory requirements guidelines for the laboratory performance of forced degradation and its application for the development of stability indicating method. There are number of strategies have been implemented for the quantitative assessment of antiviral drugs. This study will provide detailed literature on stability- indicating HPLC/ RP-HPLC approaches for the development and validation of various antiviral drugs.

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Green Chemistry is the utilisation of a set of principles that reduces or eliminates the use or generation of hazardous substances in the design, manufacture and application of chemical products. Green chemistry is about Waste minimisation at source, Use of catalysts in place of reagents, Using non-toxic reagents, Use of renewable resources, Improved atom efficiency, Use of solvent free or recyclable environmentally benign solvent systems. The introduction of the dimension of green chemistry into the assessment of analytical methods should be a natural development trend in chemistry and should coincide with its general policy. Some of the principles of green chemistry, such as, prevention of waste generation; safer solvents and auxiliaries; design for energy efficiency; safer chemistry to minimize the potential of chemical accidents; development of instrumental methods are directly related to analytical chemistry. Investigation of GAC methodologies encompasses a number of strategies to minimize or to eliminate the use of toxic substances and the generation of wastes. The main focus has been the development of new routes to minimize the amounts of side products and to replace toxic solvents. Recent trends in green bioanalytical chemistry involves various strategies as development of chiral stationary phases for HPLC separation; advances in analytical chemistry using the unique properties of ionic liquids, chemical sensors and biosensors, bio analysis based on nanoporous materials, materials-based approaches to minimizing solvent usage in analytical sample preparation, microplasmas for analytical applications of lab-on-a-chip, applications of nanomaterials in enantio separation and related techniques, recent trends in counter-current chromatography.