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COVID‐19 infection, affecting every one of us from the last year. Emerging reports have indicated thromboembolism in serious cases of COVID‐19. The aspirin is useful to reduce mortality of serious patients with acute respiratory distress syndrome without COVID‐19. Thus, we have conducted a metanalysis to find out the role of aspirin in the mortality of COVID‐19 patients using RevMan 5. A total of 10 studies containing 56 696 COVID‐19 patients were found appropriate for quantitative analysis. The quality of articles was assessed using Newcastle–Ottawa scale. The fixed‐effect model was used to calculate the odds ratio with 95% confidence interval (CI). The odd ratio was found to be 0.70 [0.63, 0.77] which indicates a lesser likelihood of having death in COVID‐19 patients in aspirin group as compared with non‐aspirin group. However, no effect 0.00 [−0.04, 0.04] was observed after the exclusion of outliers. Thus, further clinical evidence is required to make valid conclusion.

All chemicals were bought from Sigma Aldrich Chemical Company, USA and E. Merck India Ltd, India. All chemical reactions were carried out in oven dried apparatus and solvents used were dried and distilled. Column chromatography was carried out on silica gel (100-200 mess). Reactions were monitored on TLC, using silica gel 60F254 aluminium plates and visualized under ultraviolet light at 254 nm. Melting points were recorded on electro thermal apparatus. NMR spectra were recorded on BRUKER-AV400 spectrometer (Bruker Co., Faellanden, Switzerland) in DMSO-d6 ( 1 H at 400 MHz and 13 C at 100 MHz). Chemical shifts (δ) are expressed in parts per million (ppm) and J (Coupling constant)values in Hz.Multiplicities are indicated as s (singlet), d (doublet), dd (doublet of doublets), t (triplet), q (quartet), m (multiplet) and br (broad spectrum). Mass spectra were recorded on Micromass Q-Tof (ESI-HRMS). The elemental analyses were performed for all compounds on a Perkin-Elmer 240-C analyses equipment. S1.2. General synthesis of diarylpyrimidine derivatives (1-6)A mixture of different types of aromatic amines (3.37 mmol) and K2CO3 (3.37 mmol) in 10 mL DMF was stirred at room temperature for 15 min. 2, 4-dichloropyrimidine (3.37 mmol) was added and the mixture was stirred at reflux for 4-6 h. Reaction was monitored on TLC for its completion. The solvent was evaporated and residue was partitioned between water

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