In the current study, a new series of 1,2,3-triazole derivatives was synthesized via copper (I) catalyzed azide-alkyne cycloaddition reaction using a series of synthesised p-substituted phenyl azides and propiolic acid. In addition, a new series of heterocyclic compounds containing 1,2,3-triazole and 1,3,4-thiadiazole ring combined in one molecule was synthesised via a condensation reaction of the synthesised 1,2,3-triazole derivatives and thiosemicarbazide in the presence of POCl3. Furthermore, the thermal behavior of these newly synthesised compounds was studied by TGA and DTG techniques.

In the present work, a new series of compounds containing 1,2,3-triazole and 2-pyrazoline moieties in the same matrix was synthesized via a multistep synthetic route. The synthesized compounds were characterized by FT-IR, 1HNMR and 13C NMR spectra. The target compounds and their precursors were screened in vitro for their α-amylases inhibitory activity. The preliminary activity results revealed that all the tested compounds displayed an inhibition activity ranged from moderate to high depending on their structures and concentrations compared to ascorbose as a standard drug.

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The current study is interested in the study of the effect of ellagic acid on levels of glucose and albumin for diabetics of type 1. The target blood samples were collected from 52 diabetics’ type 1 (female and male). For each collected sample, the levels of glucose and albumin were firstly measured and the obtained read was recorded as a control read. A solution of ellagic acid (45 µL) was then added and the resulting solution was then incubated at 37 oC for 45, followed by measuring the levels of glucose and albumin. The same sample was then incubated again at 37 oC for further 45 minutes and the levels of glucose and albumin were then measured. For both incubation times, the obtained results showed that the addition of ellagic acid reduced the levels of glucose and albumin. Furthermore, varietal differences were observed in the levels of glucose and albumin depending on the incubation time. In addition, all obtained reads were studied statistically as a function for some risk factors such as age, weight, and gender.