Stress describes physical and mental reactions or responses to psychosocial stressors that need attention in today’s global age. Work stress arises from the interaction of individuals with work, characterized by changes in individuals who force themselves to deviate from normal functions in the work organization. Work organization is the coordination of several individual activities planned to achieve a common goal through the division of tasks, functions, authority, and responsibilities. The upsurge of Volatility, Uncertainty, Complexity, and Ambiguity (VUCA) is a global phenomenon. Hence, it is necessary to examine the impact of stress on employees in any work organization so that it needs to be reviewed previous research results. The purpose of writing this article is to describe the causes of stress levels that arise in work organizations among employees or members of the work organization. The method used is a literature review from the source of articles in the search for SAGE Journals, Emerald, and PubMed between 2018-2022, with a total of 10 articles that have been reviewed through a qualitative exposition approach. The results of the discussion show that each work organization has high work demands that cause stress in the future, so it needs prevention in training, development, adaptation, and communication to reduce the occurrence of stress that can damage the mental health of individuals.