Vitamin E memiliki banyak fungsi bagi tubuh manusia. Peran vitamin E pada kulit meliputi sebagai antioksidan, menjaga kelembapan kulit, perlindungan terhadap sinar matahari, serta proses penyembuhan luka. Sumber dari vitamin E dapat diperoleh dari minyak nabati, kacang-kacangan, biji-bijian, daging dan susu. Kekurangan vitamin E dapat diakibatkan oleh asupan makanan atau gangguan absorpsi. Gangguan absorpsi dari lemak seperti keadaan cystic fibrosis, Crohn’s disease, dapat menimbulkan defisiensi dikarenakan pembawa dari vitamin E adalah lemak. Hal ini juga dapat mempengaruhi fungsi proteksi membrane sel terhadap radikal bebas sampai dengan pengaruh pada sistem organ. Terapi vitamin E dapat berupa topikal dan sistemik. Vitamin E topikal yang digunakan sebagai komponen produk kulit memiliki efek antiproliferatif dan antiinflamasi dan pada konsentrasi antara 2 sampai 20%. Vitamin E dalam bentuk oral adalah D-α tokoferol, dengan dosis oral antara 50 IU dan 1000 IU per hari.

The safety and immunogenicity of the two-dose injections of the CoronaVac vaccine (Sinovac Life Sciences) have been reported in Phase 1 and 2 trials. 1,2 After the approval of CoronaVac by the Indonesian government, the coronavirus disease 2019 (COVID-19) vaccination program was launched in January 2021, with the first administration batch targeted towards healthcare workers. However, published data regarding the humoral immune response after Cor-onaVac vaccination in subjects not included in clinical trials are scarce. Therefore, this report aims to evaluate the effectiveness of two doses of CoronaVac vaccine by investigating the level of total Ig anti-receptor binding domain (RBD) severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). This is a retrospective study carried out using nonprobability sampling. Subjects were included based on the fulfillment of the following criteria: (1) healthy volunteers; (2) healthcare workers receiving Cor-onaVac vaccine between January and March 2021; (3) has received two doses of CoronaVac (at a 2-week interval [0 and 14 days], with each dose containing inactivated SARS-CoV-2 virus 3 mcg [600 SU] in 0.5 ml); (4) has had a measurement of the Ig anti-RBD quantified by Elecsys Anti-SARS-CoV-2 S (Roche, cut-off value ≥ 0.8 U/ml) after the second dose of CoronaVac vaccine. The Elecsys Anti-SARS-CoV-2 S serology assay is a quantitative electrochemiluminescence immunoassay (ECLIA) utilizing a recombinant protein representing the RBD of the spike antigen and captures predominantly anti-SARS-CoV-2 IgG. 3,4 This study was approved by the Faculty of Medicine and Health Science, Maulana Malik Ibrahim State Islamic University of Malang ethics committee (Ref. No. 023/EC/KEPK-FKIK/2021), and informed consent was obtained from all subjects.The Ig anti-RBD measurement time was varied, ranging from 7 to 49 days after the second dose of the CoronaVac vaccine. Subjects were hence grouped according to the time of Ig anti-RBD measurement. The Ig anti-RBD level between groups was statistically analyzed either by one-way analysis of variance (ANOVA) or paired/ unpaired t-test using SPSS version 25 with a significance threshold of p < 0.05, and all figures were generated using the Graphpad PRISM.Initially, a total of 131 subjects, consisting of 59 male (45%) and 72 female (55%) healthcare workers (mean age overall, 35.

Introduction: Giant Condylomata Acuminata (GCA) or Buschke-Lowenstein tumours are rare variations of anogenital warts. Immunocompromising conditions are closely related to the development of GCA. There is no standard therapy in the management of GCA. Its large size allows malignant transformation and high recurrence. Case Presentation: A male, 26 years old, with a complaint of wart in the anal in the last 11 months. The lump was getting bigger and sometimes bleed. The patient had been diagnosed with HIV 1 year ago and had received routine antiretroviral therapy (ARV). On physical examination of the perianal region showed stalked vegetation which was hypopigmented, partly erythema, verrucous surface, in the form of cauliflower, multiple, measuring 1.5x1.5x4 cm. A positive acetowhite test and histopathological examination showed condylomata acuminata. Patients were given combination electrocautery therapy and zinc sulfate 5-10 mg/kg/day for 2 months. Significant improvement appears and GCA disappears entirely. Conclusion: Electrocautery and zinc sulfate as an immunomodulator can be considered as a treatment of GCA with HIV because they can work synergistically to achieve resolution of the lesion and prevent recurrence of GCA.

Pemphigus vulgaris (PV) adalah suatu penyakit autoimun yang ditandai lepuhan pada kulit dan membran mukosa. Lesi primer PV adalah terdapat lepuhan kendur dengan predileksi pada seluruh permukaan kulit dan mukosa. Tes diagnostik untuk menegakkan diagnosis PV terhadap penyakit vesikobulosa yang lain, meliputi biopsi kulit ataupun mukosa untuk pemeriksaan histopatologi dan immunoflouresence (IF). Gambaran histopatologi yang ditemukan berupa adanya intraepithelial blister dan achantolysis suprabasilar dengan ciri khas row of tombstone yang merupakan hasil dari IgG autoantibodi terhadap glikoprotein desmoglein 3 (dsg3) dan sebagian terhadap desmoglein 1 (dsg1). Pemeriksaan direct immunoflourescence menunjukkan deposit IgG, IgM dan C3 di ruang antar sel dalam epitel.