We conclude that significant number of patients with laryngeal cancer presented with locally advanced disease and dysphonia was the commonest symptom.

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SummaryWe present a case of disseminated invasive aspergillosis in a young male adult with progressive complex gastrointestinal, non-specific peripheral neural and respiratory symptoms and subsequent acute haemorrhagic conjunctivitis and generalized dermatitis.The case emphasizes the difficulty in diagnosing systemic mycosis and a high index of suspicion is recommended particularly in patients on prolonged antibiotics and systemic steroids.

This study was aimed at utilizing retrospective descriptive data to evaluate the percentage of clinically benign breast lumps that turned out to be histologically malignant and the prevalence of positive tumour margins among the malignant cases. A total of 2,917 registered cases of excised breast lump at the Department of Pathology spanning January 2005 to December 2009 were reviewed to evaluate the presence of malignancy and positive margins. Three hundred and twenty-two (11.0%) of the excised breast lumps were found to contain malignant tumours, out of which 142(44.1%) had positive tumour margins. Size of primary tumour (p=0.001) and histologic subtype (p=0.002) showed significant positive and negative associations in relation to positive tumour margins respectively. No significant association was observed between the positive tumour margins and histologic grade (p=0.363).The study showed that clinically benign breast lumps could be malignant and not completely excised, therefore increasing the risk of local recurrence. Thus, it is recommended that all women with breast lumps have the triad (diagnostic workup) of clinical and radiological assessment, followed with histological studies.

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