Lymphedema, a chronic incurable condition characterized by edema, inflammation, reactive fibrosis, adipose proliferation, and compromised immune function, affects over 250 million people worldwide [1]. Further, a comorbidity of obesity increases the risk of developing lymphedema and can result in irreversible damage to lymphatic function. Access to appropriate and timely lymphedema treatment, performance of proper self-management strategies, and implementation of healthy lifestyle practices are critical for optimal outcomes for those affected. It is vitally important that a healthy lifestyle program for patients diagnosed with lymphedema include strategies for addressing both lymphedema and weight management. In this paper, we describe the essential elements of a successful program for lymphedema and weight management: ketogenic nutrition, exercise, stress resilience, and sleep.