Taken together, the data suggest the miRNA34s might be key effectors of p53 tumor-suppressor function, and their inactivation might contribute to certain cancers.

Some management science models require estimates of distances between points in a road network based on the point coordinates. This paper evaluates the accuracy of a range of reasonable forms for distance estimating functions using samples of urban and rural road distances. The intent is to derive better distance estimating functions for analyzing systems with distance related performance measures. Contrary to a standard assumption, the rectangular distance function is inferior to the simple Euclidean metric in the urban samples. More general functions provide still greater improvement over the rectangular metric. Statistical significance accompanies these conclusions. One of the more general functions appears particularly suited to rural distances.transportation: road, statistics: estimation, planning: urban

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Thirty-live male undergraduates were divided into three groups on the basis of their scores on Masher's Forced-Choice Guilt Inventory. The amount of time subjects spent viewing and rating photographic slides of varying erotic content was unobtrusively recorded. The viewing time of the low sex guilt group increased linearly as a function of increasing pornographic content. There was no significant increase in viewing time for high sex guilt subjects. Members of the moderate sex guilt group exhibited a curvilinear viewing pattern. These results arc consistent with a predicted defensive response on the part of high sex guilt subjects, thus supporting Mosher's conceptualization and measure of sex guilt.Psychological research in the area of pornography has begun to increase largely as a result of the appointment of the Commission on Obscenity and Pornography by Congress in 1967. The present study grew out of research supported by the Commission and carried out by Amoroso, Brown, Pruesse, Ware, and Pilkey (1970) and Mosher (1970). These studies investigated the relationship between guilt feelings toward sex and voluntary exposure to erotic visual stimuli. The impetus for this study arose from a desire to test the popularly held concept that persons who advocate suppression of sexually oriented material arc often suppressing their own feelings about sex. Although they publicly condemn this material, such people privately enjoy being exposed to that which they condemn. The archetype of this type of person is, of course, the conservative member of the movie censor board.The Sex Guilt subscale of the Mosher Forced-Choice Guilt Inventory (FCGT; Mosher, 1966) was selected as an appropriate dispositional measure of guilt feelings toward sex. Sex guilt, as defined by Mosher's scale, is a "generalized expectancy for self-mediatedThe authors would like to thank Walter M. Baker for his help in completing this study and Thomas M. Ostrom and Anthony G. Greenwakl for their helpful comments.Requests for reprints should be sent lo Robert K.

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