Metallic balloon-expandable stents are effective in relieving lower tracheomalacia and bronchomalacia in select patients. Only patients in whom conventional therapy has failed should be considered for stent placement.
A B S T R A C T The plasma low density lipoproteins (LDL) in biliary obstruction are characterized almost exclusively by the presence of the immunochemically distinct lipoprotein families, lipoprotein B (LP-B) and lipoprotein X (LP-X). It is suggested that LP-X, with its uniquely high content of unesterified cholesterol and phospholipid, is primarily responsible for the unusual lipid composition of LDL and the abnormal plasma lipid composition in obstructive jaundice.To show their protein moieties, we isolated LP-X and LP-B from the LDL in plasma obtained from patients with obstructive jaundice. A separation procedure was employed which combines ultracentrifugation, heparin precipitation, and ethanol fractionation. Whereas LP-B was characterized by the presence of apolipoprotein B (ApoB), intact LP-X contained a protein moiety of unique composition consisting of a mixture of albumin (approximately 40%) and the specific apolipoprotein,
A method has been developed for the fractionation of very low density (VLD) human serum lipoproteins (Sf >20) by angle-head preparative ultracentrifugation. A buffer solution of density 1.006 g/ml is layered over serum and both centrifugal force and time ("g min") are increased in each successive run.A procedure was standardized for the separation of VLD-lipoproteins into five subfractions. Each subfraction, freed of contaminating serum proteins, has been characterized by determination of flotation coefficient, anhydrous density, concentration dependence of Sf
The partial delipidization of human serum cient, diffusion coefficient, hydrated density, N-terminal a-and /3-lipoproteins by «-heptane resulted in phos-amino acids, by peptide patterns, and by immunopholipid-protein residues characterized by a single chemical specificity. The protein moieties of two of the protein moiety, apolipoprotein A and apolipoprotein B, three VLD phospholipid-protein residues were the respectively. The very low density (VLD) lipoproteins same as apolipoproteins A and B. The third phospho-(Sf >20) yielded, upon partial delipidization, a mixture lipid-protein residue contained another protein, desigof three phospholipid-protein residues. These were
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