The effects of specific immunotherapy with allogeneic cells transformed by Schmidt-Ruppin Rous sarcoma virus (SR-RSV), of treatment with BCG, and of surgery on the growth of SR-RSV-induced sarcomas in white-lipped marmosets were studied. Tumor incidence, tumor progression, and survival did not differ between control and treated animals. Animals immunized with BCG developed lymphocyte reactivity to tuberculin, which remained until the animals died. BCG was isolated from the spleen of one tumor-bearing animal.

Clinical and immune responses of marmosets to BCG immunization were studied. Ten of 13 animals responded to BCG immunization by developing lymphocyte reactivity to purified protein derivative (PPD), while the lymphocytes of only 3 of 64 unimmunized animals showed reactivity to PPD.