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Gastrointestinal bleeding (GIB) caused by stress ulceration is a recognized condition that can affect intensive care unit (ICU) patients, and increases mortality and morbidity rates (Cook et al., 2001;Negro, Villa, Rolandi, Lucchini, & Bambi, 2022). Overt GIB is defined as visual evidence of gastrointestinal (GI) bleeding with hemodynamics and hemoglobin levels being affected or requiring transfusion (Granholm et al., 2019). Risk factors associated with overt GIB are coagulopathy, shock, sepsis, acute hepatic failure, chronic liver disease, acute kidney injury, male gender, and acute myocardial infarction (Granholm et al., 2019). Critically ill patients affected by coronavirus disease-2019 (COVID)-19 need prophylactic anticoagulation therapy to reduce the complications caused by immobilization and thromboembolic risks (Thachil et al., 2020). although this treatment will protect from a thromboembolic event, it can increase the risk of bleeding.