Semi-arid regions have historically suffered from low water availability. In addition, the increasing frequency and intensity of extreme weather events credited to global climate change has made it increasingly clear that among the challenges faced by society water resource management is extremely necessary. In this context, desalination based on renewable energy resources integrated with production systems that make use of the waste resulting from this process becomes a socio-environmentally indicated alternative to expand existing supply strategies and sustainable water use in isolated locations, and/or areas distant from large urban centers, thus addressing local potential and reducing environmental impacts. This study assesses the use of Photovoltaic Solar Power Plants (PSPPs), as well as of residues generated in a Brackish Water Reverse Osmosis System (BWRO), in productive units linked to fish and family farming. This is as an alternative way to reduce water vulnerability in the Brazilian semi-arid area (BS), adhering to climate change adaptation measures in the light of Brazilian public policies through the Freshwater Program (Programa Água Doce—PAD), which aims to promote access to good quality water to approximately 500 thousand people in the Brazilian semi-arid region.