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The effect of estriol on the response of human umbilical artery to bradykinin (0.2 µg/ml) and adrenalin (0.8 µg/ml) was studied by an in vitro perfusion method. Estriol (10 µg/ml) added to the nutrient medium decreased the response of the preparation to the two vasoactive agents. The results suggest the participation of estriol as a modulator of the vascular response at the level of the umbilical circulation, where it may act to protect the maternal-fetal circulatory system from physical or chemical stimuli.

Diabetes mellitus define um grupo de alterações genética e clinicamente heterogêneas que têm em comum a intolerância aos