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This paper is dedicated to Professor P. Joseph-Nathan for his 65 th birthday. A comparative study of the reactivity of two sesquiterpene quinones, perezone and isoperezone, with a series of five mercaptans, using three different modes of activation (thermal, infrared and microwave irradiations), and under the presence or absence of solvent was performed.

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2005 Medicinal chemistry V 1100 Synthesis and in vitro Antitrypanosomal Activity of Novel Nifurtimox Analogues. -The synthesis of novel analogues (I) of Nifurtimox, a 5-nitrofuran derivative, and their in vitro activity against Trypanosoma cruzi epimastigotes are described. (Ia) and (Ib) are the most potent compounds. The change of O by S, cf. (Ic), reduces the activity. -(POZAS, R.; CARBALLO, J.; CASTRO, C.; RUBIO*, J.; Bioorg. Med. Chem.

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