FOR over forty years the only recognized form of coccidioidal disease was the usually fatal progressive coccidioidal granuloma. Then the recognition by Gifford and Dicksonl-4 that Coccidioides immitis causes an illness which is benign and selflimited enormously broadened this concept. Their addition of coccidioidal erythema nodosum (" Valley Fever") created a true disease spectrum.5'6 However, many questions were raised in the process. Coccidioidin skin testing had shown that a large proportion of the individuals of the southern San Joaquin Valley reacted, yet the coccid-* From the Commission on Epidemiological Survey of the Board for the Investigation of Epidemic Diseases, Preventive Medicine Services, Office of the Surgeon General. The special studies on coccidioidomycosis have been conducted in the

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In establishing improved standards of air quality, the effects of pollutants on human performance should be taken into account. For this reason, the effects of exposure to carbon monoxide were studied on a group of young adults. The results are reported.

A FTER we began preparing coccidioidin from asparagine synthetic medium 1 and distributing it on request, reports received indicated that the material was specific and that the coccidioidal endemic area of the United States was confined to the arid Southwest. The first seriously discordant note was the experience of Furcolow and Nelson in an orphanage in Ohio 2 wherein a considerable number of * Presented before the Epidemiology Section of the American Public Health Association at the Seventysixth Annual Meeting in Boston, Mass., November 11, 1948. These investigations are an activity of the Commission on Acute Respiratory Diseases, Army Epidemiological Board, Office of the Surgeon General, Department of the Army. The study of coccidioidomycosis has been carried out at the