Obesity negatively affects the relationship between markers and micronutrients of bone metabolism. Testing the hypothesis that the metabolically healthy obese phenotype might be protected by those alterations was the aim of this study. A cross-sectional study was carried out in adults with class III obesity classified in Metabolically Healthy Obese (MHO) and Metabolically Unhealthy Obese (MUHO), according to the National Cholesterol Education Program Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (NCEP ATP III) criteria. Anthropometric, biochemical, and clinical variables were analyzed for sample characterization. To evaluate bone metabolism, markers (alkaline phosphatase and parathyroid hormone—PTH) and related nutrients (vitamin D, vitamin B12, calcium, phosphorus, magnesium, potassium and zinc) were analyzed. A total of 223 adults with class III obesity aged 41.20 ± 10.15 years were included. The MHO phenotype was identified in 32.73% of the sample. After logistic regression, it was observed that inadequacies of calcium (OR: 4.11; 95% CI: 2.33–6.66), phosphorus (OR: 3.03; 95% CI: 1.98–5.79), vitamin D (OR: 5.01; 95% CI: 2.92–6.71) and PTH (OR: 5.45; 95% CI: 4.49–6.74) were significantly higher in the MUHO group compared to the MHO Group. This study showed that the MHO phenotype does not protect adults from alterations in markers and micronutrients of bone metabolism. However, the MUHO phenotype presents a higher risk for alterations related to bone metabolism, which can favor the emergence of metabolic bone diseases.

RESUMOConduziu-se o estudo do perfil metabólico, com o objetivo de avaliar o estado nutricional ou possíveis distúrbios metabólicos que podem comprometer a saúde e, consequentemente, o desempenho do rebanho. No presente trabalho foi avaliado o perfil metabólico de cabras em lactação, submetidas a dietas com diferentes fontes de lipídios. Foram utilizadas 16 cabras da raça Saanen com peso vivo médio de 35 Kg e produção média diária de 1,2 kg de leite, distribuídas em quadrado latino com três repetições. Os tratamentos experimentais consistiram nas seguintes dietas: sem suplementação lipidica (TC); semente de faveleira (SF); torta de faveleira (TF) e caroço de algodão (CA). O experimento foi desenvolvido em quatro períodos experimentais de 14 dias, sendo 10 dias de adaptação à dieta e quatro dias de coleta de dados. No último dia de cada período foram coletadas amostras de sangue. A inclusão de semente de oleaginosa na dieta de cabras em lactação diminuiu o consumo de matéria seca por unidade metabólica (CMSU) e consumo de proteína bruta por unidade metabólica (CPBU). Dentre os quatro tratamentos não se observou diferença significativa no que se refere à concentração sérica de uréia, creatinina, GGT (gama glutamiltransferase), cálcio, fósforo, magnésio e glicose. Os níveis séricos de albumina dos animais que receberam TF foram maiores (P<0,05) do que os animais do grupo controle. Este trabalho sugere que as fontes de oleaginosas podem ser utilizadas na suplementação lipídica de cabras Saanen em lactação, entretanto animais alimentados com TF apresentaram um perfil metabólico mais saudável em função da suplementação lipídica.Termos para indexação: Caprinos leiteiros, faveleira, perfil protéico, manejo alimentar. ABSTRACTThe study of the metabolic profile has as objective to evaluate the nutritional status or possible metabolic disturbances that can damage the health and consequently the herd performance. In this work, the metabolic profile of lactating goats was evaluated, submitted to diets with different fat sources. 12 Saanen goats with BW of 35 kg and daily milk production of 1,2 kg were used, distributed into a Latin square with three repetitions. The diet comprised, without fat supplementation, TC (control) and with fat supplementation: SF (favelone seed); TF (favelone cake) and CA (cotton seed).The experiment was developed in four experimental periods of 14 days, with 10 days of adaptation to diets and four days for samples collection. In the last day of each period were collected blood samples. The inclusion of oleaginous seed into the lactating goats' diet decreased the dry matter consumption for metabolic unit (CMU) and consumption of crude protein for metabolic unit (CPMU). No significant differences in serum urea, creatinine, GGT (gamma glutamyltransferase), calcium, phosphorus, magnesium or glucose values were noticed in any of the four treatments. The serum levels of albumin in the animals that received TF were higher (P<0.05) than the animals of the control group. This work suggests that the oleagino...

Pesq. Vet. Bras. 33(6):780-784, junho 2013 780 RESUMO.-Objetivou-se com este estudo determinar a frequência de antígenos eritrocitários do sistema AB em felinos domésticos da Paraíba, Brasil. Foram selecionados aleatoriamente 178 gatos, clinicamente saudáveis, sem pré-requisitos quanto a sexo ou raça, com peso corporal acima de 1,5 kg e faixa etária acima de um ano de idade, The objective of this study was to determine the frequency of the AB blood group antigens system in domestic cats of Paraíba, Brazil. We randomly selected 178 cats which were clinically healthy, with no prerequisites in terms of gender or race, weighing above 1.5 kg, and were over one year of age. These cats were randomly selected when they entered the small animal clinic facilities in the cities of João Pessoa, Campina Grande and Patos. The determination of blood types was made using the hemagglutination test tube, and the reverse typing was performed for samples B and AB types and for confirmation of alloantibodies natural disclosure. In this study the relative frequency of A, B and AB blood group antigens in cats without a determined breed was 98.1%, 1.21% and 0.69% respectively. All cats with breed definition were blood type A. The likelihood of random transfusion reactions was 2.78%, approximately 40% (1.11%) potentially fatal. Thus, given knowledge of the frequency of different blood types in cats, from a given region, it is concluded that blood typing and compatibility test are important tools that enable the veterinarian to take preventative measures to minimize risks of isoelectrolisys reactions and neonatal transfusion, and establishes prerequisites about the risks of hemotherapic procedures in cats that require circumstantially to be conducted randomly.INDEX TERMS: Immunohematology, blood types, erythrocyte antigens, cats.abordados no ato da consulta ambulatorial em clínicas mé-dicas de pequenos animais distribuídas entre três cidades da Paraíba (João Pessoa, Campina Grande e Patos). A determinação dos tipos sanguíneos foi realizada através do teste de hemaglutinação em tubo de ensaio e, a tipagem reversa foi realizada para as amostras tipos B e AB para confirmação e evidenciação de aloanticorpos naturais. Neste estudo a frequência relativa de antígenos eritrocitários A, B e AB em sua totalidade para felinos sem raça foram 98,1%, 1,21% e 0,69%, respectivamente. Todos os felinos com definição racial foram do tipo sanguíneo A. Diante destes, a probabilidade de ocorrência de reações transfusionais aleatórias obtidas foi de 2,78%, sendo cerca 40% (1,11%) potencialmente fatais. Desta forma, dado o conhecimento da frequência dos diferentes tipos sanguíneos em felinos, de uma determinada região, conclui-se que a tipagem sanguínea e o teste de compatibilidade, são importantes ferramentas que permitem ao médico veterinário tomar

PurposeTo describe clinical, biochemical and anthropometric profiles in adults with class III obesity classified as metabolically healthy obesity (MHO) and metabolically unhealthy obesity (MUHO).Patients and methodsThis is a cross-sectional study with patients classified as MHO and MUHO according to the NCEP-ATP III. Anthropometric, biochemical and clinical variables were analyzed.ResultsA total of 223 subjects were evaluated and 32.73% were classified as MHO and 67.26% as MUHO, respectively. The insulin resistance homeostasis model (HOMA-IR) showed elevation in the MUHO group (p=0.003) and anthropometric variables were correlated with bone markers [body index mass (BMI) vs phosphorus: r=0.31, p<0.001; BMI vs 25(OH)D: r=−0.31, p=0.041]. Visceral adiposity index was lower in MHO (p=0.001). Negative correlations between inflammatory markers and bone markers were observed in the MHO group (calcium vs C-reactive protein: −0.30, p=0.017; parathyroid hormone vs HOMA-IR: r=−0.28, p=0.017.ConclusionMHO individuals showed important metabolic changes, such as those observed in MUHO, despite lower prevalence and severity. Continuous monitoring of these individuals is suggested, given the transient nature of the MHO phenotype.

ResumoA Tetralogia de Fallot (TF) é uma cardiopatia congênita causadora de cianose, reconhecida, classicamente, como a combinação de quatro defeitos. Sua fisiopatologia está intimamente relacionada com dois defeitos que interferem significantemente na hemodinâmica do animal: a estenose da valva pulmonar e o defeito septal interventricular, sendo que suas conseqüências dependem sensivelmente da magnitude destes defeitos. Atualmente, existem vários métodos de diagnóstico, capazes de elucidar com precisão essa cardiopatia congênita. Existem varias modalidades de tratamento, que vão desde terapia medicamentosa a procedimento cirúrgico corretivo, sendo que, atualmente a técnica mais empregada é o método cirúrgico paliativo de Blalock-Taussig.Palavras-chave: Tetralogia de Fallot, cardiopatia congênita, Blalock-Taussig