We have analysed the causes of death in a group of patients with chronic renal failure – serum creatinine more than 225 µmol/l (2.5 mg/100 ml) – and find that there is an increased incidence of malignancy when compared with the fatality rates for cancers in England and Wales (p < 0.0005). No patient in the series had received a transplant kidney or was therapeutically immunosuppressed for other reasons.
The date of onset of 360 acute renal transplant rejection episodes from 1969 to 1973 have been compared with the prevalence of various common viral infections and infections due to Mycoplasma pneumoniae. A positive correlation was found for influenza B infections (r = 0.43, p < 0.01) up to 5 months before transplantation and for adenovirus infections (r = 0.32, p < 0.05) at 1 month before kidney grafting.
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