Titanium is known to possess excellent biocompatibility as a result of corrosion resistance, lack of allergenicity when compared with many other metals. Fluoride is well known as a specific and effective caries prophylactic agent and its systemic application has been recommended widely over recent decades. Nevertheless, high fluoride concentrations impair the corrosion resistance of titanium. The purpose of this article is to summarize the current data regarding the influence of fluoride on titanium corrosion process in the last 5 years. These data demonstrate noxious effects induced by high fluoride concentration as well as low pH in the oral cavity. Therefore, such conditions should be considered when prophylactic actions are administrated in patients containing titanium implants or other dental devices.

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Polyphenols are abundant in red grapes and in their derived products, amongst other natural food sources. These compounds are associated with the prevention of diseases caused by oxidative stress. The present review discusses the action of grape polyphenols against diseases and the new polyphenol-rich products developed to be used as nutraceuticals. Grape polyphenols demonstrated effects such as maintenance of endothelial function, increase in antioxidant capacity and protection against LDL oxidation. Recent patents regarding polyphenols show a tendency to use a right-on-target approach and the new patented products are aiming at preventing and treating specific diseases.

The inhalation promoted by cigarettes in dry form is widely used due to greater effectiveness. It is estimated that 0.5-1 g of the plant contains 20 mg of THC. This in turn is consumed in the form of tetrahydrocannabinolic acid as a result of combustion of the plant (Bonfa et al., 2003). The acid then converts into free THC, where it is absorbed through inhalation; the smoke goes to the lungs allowing the bioactive substances to reach the bloodstream and central nervous system (Bonfa et al., 2003). Marijuana is considered an illicit drug in many countries, such as Brazil, where it is widely consumed by people in general who justify its use to produce relaxation, and decreased stress and anxiety (Zuardi et

The ketogenic diet (KD) was initially developed for the treatment of pharmacoresistant epilepsy and a possible alternative for the obesity treatment, dyslipidemia, resistance to insulin, and nonalcoholic steatosis. However, few studies evaluate the diet effects in rats behavior or cicatrization. The objective of this work was to analyze the influence of the ketogenic diet on the weight gain, emotional behavior of the rats submitted to experimental models such as elevated plus maze (EPM) and open field (OF). The cicatrization time and leukocyte differentiations were also observed. Twenty male Wistar rats of two months age were divided into two groups. One was submitted to ketogenic diet (KD), and the control group (Co) was fed on commercial rations. After 7 days, the animals were weighed and submitted to EPM and OF. A small surgical incision was made and their blood was collected to a leukocyte count. It was verified that the rats from the KD presented less weight gain as compared with the rats from the Co (p < 0.05). The KD did not reveal differences on the behavior measures in the EPM model, but in the OF presented an ambulatory activity significantly bigger. The animals from the KD presented a cicatrization significantly better than Co after 72 h (p = 0.0035) and 96 h (p < 0.1). There was no difference between the groups for leukocyte count. Our results suggest that the KD can interfere on rats deambulation in animal models and improve the cicatrization response.