Oral cancers are one of the leading cancers in the world.However ,in India,it is one of the most common cancer and a major public health problem.The purpose of this study was to evaluate retrospectively the demographics,histopathological and clinical profile of patients with oral cancer reported at a tertiary level referral hospital in Central India.A total of 908 biopsy proven OSCC cases were retrospectively analyzed and data was collected for a period of 7 years from January 2007 to December 2013 with reference to age,sex,site involved,habits,TNM staging and final diagnosis based on histopathological findings and the results were formulated to chart the trends in central India population.Male to female ratio was 2.54 : 1. Most of the patients of OSCC were in the age group of 51-60 years (28.52%) .The most common site of presentation of primary tumor was mandibular alveolus region.Tobacco chewing along with smoking was the major cause for the development of OSCC(25.66%).Majority of the patients were presented in Stage IV (45.94%) and histopathologically well differentiated squamous cell carcinoma(54.95%) was the most common presentation.This study showed that OSCC is wide spread in the patients of this region and most of the cases report at advanced stages of the disease due to lack of awareness among the common masses.To decrease the morbidity and mortality associated with OSCC ,early detection of localized lesions combined with appropriate treatment is required.

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The current study aims to present our clinical observations and experience gathered during the diagnosis, clinical presentation, medical/surgical treatment, and functional prosthetic rehabilitation of cases of rhino-orbital/cerebral Mucormycosis patients. Mucormycosis is an aggressive, life-threatening invasive fungal infection that occurs in people who are immune-compromised. The rise of ROCM during the second wave of the COVID-19 pandemic in India suggests a more effective association between Mucormycosis and the SARS-CoV-2 delta variant. The treatment strategy for Mucormycosis is an early diagnosis which is critical for a successful outcome. The initial step is to reduce or remove underlying risk factors followed by surgical excision and debridement of the afflicted tissues supplemented with antifungal medication. The first-line antifungal treatment is Liposomal Amphotericin B. Postsurgical resection defects are rehabilitated by either removable partial prosthesis (obturators) or by fixed zygomatic implant/patient-specific implant supported prosthesis. Management of ROCM requires a multidisciplinary approach. This case series highlights detailed medical, surgical, and functional prosthetic management modalities adopted by our team in managing such a dreaded disease which may be used as a tool for the formulation of standardized prevention and management/treatment/rehabilitation protocols in the future so that disease morbidity and mortality be reduced and an endemic outbreak could be averted.