Several andrographolide derivatives (I) and (II) are synthesized and evaluated for their anti-HIV activity in a cell-free virus infectivity assay. As compared to andrographolide, derivative (IIc) shows higher in vitro anti-HIV activity, whereas compound (Ia) displays a higher therapeutic index. -(UTTEKAR, M. M.; DAS, T.; PAWAR, R. S.; BHANDARI, B.; MENON, V.; NUTAN; GUPTA, S. K.; BHAT*, S. V.; Eur. J. Med. Chem. 56 (2012) 368-374, http://dx.
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