Earthquake is one of the most dangerous hazard among the natural calamities. Due to the earthquake, many damages causes to the structure and loss of life occurs. Hence one of the most appropriate method is developed to reduce these damages is seismic base isolation. Among the variety of different isolators lead rubber bearing plays an important role. Base isolation reduces the acceleration and storey shear but at the same time it increases the time period and storey displacement which imparts the flexibility to the structure and makes the structure rigid by dissipating energy to the foundation. The study investigates seismic response of the structure after the use of lead rubber bearing as well as friction isolator. In this study, the dynamic response of multi storey RC structure shows that quantities are upto some extent which reduces the structural damages. I.