Background: Approximately 10% of Crohn’s disease (CD) patients have this disease affecting the small bowel (SB) beyond the reach of Ileo-colonoscopy. Capsule endoscopy (SBCE) is the recommended investigation for SB disease. An accurate and inexpensive biomarker would help identify at-risk patients. Aim: To examine the efficacy of faecal calprotectin (FC) and C-reactive protein (CRP) as predictors of SBCE findings in suspected and known CD. Methods: A prospective observational study. Consecutive patients referred for SBCE gave FC and CRP samples. The diagnostic accuracy for SB CD based on SBCE result was calculated for both FC and CRP. Results: Of 100 invitees, FC and SBCE results were available in 64 cases. Correlation between FC >50 µg/g and SBCE result was poor К = 0.163; sensitivity, specificity, positive predictive value (PPV) and negative predictive values for ileitis were 60, 61, 32 and 83% respectively. PPV and specificity improved at FC >100 µg/g, 76 and 40%, correlation remained fair, К = 0.259. Receiver operating characteristic analysis had a sensitivity of 47% and specificity of 90% for FC >194 µg/g. CRP alone or in combination was an inaccurate predictor of ileitis. Conclusion: Our study suggests that FC level >194 µg/g may be a useful SBCE filter test, identifying patients at risk of SB CD.

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Results Out of 77 transfusions, 40 (52%) were collected during the working hours while 37(48%)were collected out of hours. Nearly (40)52% patients were stable at the time of transfusion and 25(32%) were unstable and 12(16%) were not recoreded.Median gestation and weight was at birth was 28 +3 weeks and 1.14 kg respectively. Median Day of Life at transfusion was 22. Median Hb level before transfusion was 104.5. Conclusion A significant proportion of out of hour's orders are collected 5 to 7pm -could there be time savings made to get these within the 5 pm cut off.More than half times when patients got transfused out of hours were stable. Could there be introduction of new guidelines in terms transfusing treatment in stable patients.Out of hours transfusions carries risk of increased work load on staff and costs more if transfusion pack is not available in the hospital.