Introduction: Adverse drug reaction (ADR) reporting is an important role of pharmacist apart from preparation and dispensing of prescribed drugs. A pharmacist can also educate the physicians and nurses, and can encourage participating in ADR reporting program. ADR is a major health problem that occurs worldwide and lack of ADR reporting makes it even more upsetting. Objectives: To assess the Knowledge and Attitude of final year undergraduate pharmacy students towards ADR reporting. Methodology: Descriptive, cross-sectional study was performed in 88 final year pharmacy students in selected colleges of Kathmandu valley that are affiliated to Purbanchal University. Printed Questionnaires were used to collect the data and collected data were reviewed, coded and analyzed by using SPSS version 16.Findings: Majority of the participants were female and were age group 20-25 with mean age 24.46 years. There is significant difference in knowledge of ADR reporting between male and female. Conclusions: Majority of the participants (i.e. 95.45%) have good knowledge on ADR reporting and final year pharmacy undergraduate students have good attitude towards ADR reporting. Therefore, to enhance ADR reporting pharmacist should be encouraged.