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64HUMAN PREMOTOR CORTEX animal protein in the diet did not prevent or delay the onset of lathyrism, since characteristic symptoms were observed in 3% to 5 weeks.In a second series the effect of cold water extracts of the peas was studied. Lathyus peas were extracted overnight at 0" with distilled water, the fluid decanted and extraction repeated 3 times. The combined extracts were evaporated to a thick syrup in VQCUO.Edible split peas were similarly extracted. To the split pea residue was added the extract of the Lathyrus peas and to the Lathyrus residue, the split pea extract. The combined extract and residue in each case were dried in thin layers at 80", ground finely and incorporated into the diets, as described above. -411 of the rats receiving the Lathjwrs ex t rac t-s?li t pea residue developed acute lathyrism in from 2>2 to 4:/. weeks, while none of the rats receiving the split pea extract-Lathyrzrs pea residue diet showed any symptoms in 7 to 8 weeks. It thus appears that the toxic substance is readily extracted from h t h j w s meal by cold water and that the extracted residue is relz-tively non-toxic. This is in accord with the findings of Geiger," who extracted peas with boiling water.Pathological studies of the bones made with the cooperation of Professor Carl V. Weller revealed changes in the long bones of the leg similar to those observed in acute scurvy. The rat is believed to be able to synthesize ascorbic acid and does not require the preformed dietary vitamin. I t was believed that the toxic principle of Lathyrus odoratus might either affect tne synthesis of ascorbic acid or in some way increase the requirement beyond the capacity of synthesis of the organism. In a third series, rats fed the sweet pea diet were paired, one animal of each pair receiving in addition 12 mg of ascorbic acid. All of the aninials showed symptoms of acute lathyrism within the usual period of time. No preventive effect of the ascorbic acid could be demonstrated.Further experiments designed to determine the Rature of the toxic principle are in prcgress.The collateral systems (thalamus, basal ganglia, cerebellum, and premotor cortex) which play such a prominent role in human motor activity are particularly refractory to experimental manipulation, due to the fact that complex motor dysfunction is peculiarly human an+. has no certain counterpart in lower mammals. I t is desirable, therefore, to employ human material for information relative to the motor complex. This report serves to clarify certain points concerning the anatomy and function of the human premotor region. cision (Klemme) for the relief of generalized tremor in both upper extremities, moderate tremor and rigidity of the left lower extremity, and tremor of the tongue. The right side was operated first with relief of the contralateral tremor. The left side was operated 9 months later, the patient expiring on the seventh post-operative day. At no time was there loss of volitional movement, the residua being generalized weakness, more marked on the left, and inab...

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