We conclude that the anxiety level is increased and that experienced happiness is decreased in patients prone to recurrent severe hypoglycemia.

Adult hypophysectomized male rats were treated with 2 mg/day of testosterone propionate, pregnenolone, 17alpha-hydroxypregnenolone, progesterone or 17alpha-hydroxyprogesterone. The treatment commenced on the day of surgery and was continued for 4 weeks. In all steroid treated animals, spermatogenesis was qualitatively maintained. Sex accessory organs were maintained only in testosterone propionate treated animals. In C21 steroid-treated rats the sex accessory organs showed atrophy similar to untreated hypophysectomized animals suggesting lack of peripheral conversion to androgens. However, administration of 3H-pregnenolone with the last injection of pregnenolone resulted in the isolation of a considerable amount of 3H-testosterone from testicular tissue of the experimental animals. This finding suggests that maintenance of spermatogenesis in pregnenolone treated animals could have been due to testosterone formed in the testes from the exogenously administered pregnenolone.

We describe the plasma levels of FSH and LH in ten patients with gonadal dysgenesis during treatment with a low dosage sequential estrogen-progestogen preparation. The daily dose of mestranol ranged from 12.5--50 microgram. Norethisterone was administered from day 16 onwards, the dose ranging between 0.75 and 1.5 mg. It was shown that 25 microgram mestranol was effective in lowering the elevated FSH levels significantly (alpha < 0.001). LH levels remained unaffected. The combination of 25 microgram mestranol and 1 mg norethisterone produced an increase of FSH and LH within 12 h, maximum levels being reached within 36 h after which there was a progressive decline. Low doses of estrogen and progestogen appeared capable of evoking physiological hypothalamic and pituitary responses in patients with gonadal dysgenesis. The doses employed were sufficient to induce breast development, growth of sexual hair, and withdrawal bleeding and were probably not high enough to induce rapid bone maturation and consequent stunting of growth.

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