Key PointsQuestionIs the anti–interleukin-1β antibody canakinumab effective to treat patients hospitalized with COVID-19 and hyperinflammation?FindingThis randomized clinical trial included 454 patients hospitalized with severe COVID-19 not requiring invasive mechanical ventilation (IMV) and with elevated C-reactive protein or ferritin levels. Treatment with intravenous canakinumab vs placebo resulted in survival without IMV at 29 days of 88.8% vs 85.7%, a difference that was not statistically significant.MeaningAmong patients hospitalized with severe COVID-19, treatment with canakinumab, compared with placebo, did not significantly increase the likelihood of survival without IMV.

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An investigation of the effect of hydrogen peroxide (H 2 O 2 ) on corrosion crack growth can be considered as a necessary stage in a study of the SCC of pipeline steels in the presence of dissolved oxygen and other oxidants. It was found that the presence of hydrogen peroxide at a low concentration (5 mM) results in a deceleration of the crack growth. With an increase in the concentration of H 2 O 2 , the crack growth rate increases. The change in the steel corrosion rate at various H 2 O 2 concentrations agrees with the dependence of the crack growth rate on the oxidant concentration. The conclusion has been made that the crack growth in a weakly acidic electrolyte (pH 5.5) is determined by the metal dissolution process. Hydrogen charging of the metal indirectly affects the crack growth by increasing the surface coverage with hydrogen, which decreases the steel dissolution rate.