Highlights d High-throughput screening identifies specific small-molecule PAPD5 inhibitor BCH001 d BCH001 restores telomere length in iPSCs from patients with dyskeratosis congenita d Repurposed HBsAg suppressors, dihydroquinolizinones, increase TERC in stem cells d Oral PAPD5 inhibitors restore TERC and telomeres in human HSPCs in vivo
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