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INTRODUCTION: Supply network design is a long-studied topic that has evolved to address disruptive situations. The risk of supply chain disruption leads to the development of resilient supply chains that are capable of reacting effectively.OBJECTIVES: In the context of public health, drug supply networks face shortage challenges in many situations, such as current epidemic outbreaks such as COVID-19. Drug shortages can occur due to manufacturing problems, lack of infrastructure, and immediate reaction mechanisms.METHODS: The case study is solved with anyLogistix optimization and simulation software.RESULTS: We present the results of a hypothetical study on the impact of COVID-19 on a regional supply network. The results of this research are intended to be the basis for the design of resilient supply chains in epidemic outbreaks.CONCLUSION: Drug providers should consider strategies to prevent or reduce the impact of shortages as well as disruption spreads.

The maternal mortality situation is analyzed in México as an indicator that reflects the social development level of the country and was one of the millennial development objectives. The effect of a maternal death in the related social group has multiplier effects, since it involves family dislocation, economic impact and disruption of the orphans' normal social development. Two perspectives that causes of maternal mortality were analyzed, on one hand, their relationship with social determinants and on the other, factors directly related to the health system. Evidence shows that comparing populations based on group of selected variables according to social conditions and health care access, statistically significant differences prevail according to education and marginalization levels, and access to medical care. In addition, the Age-Period-Cohort model raised, shows significant progress in terms of a downward trend in maternal mortality in a generational level. Those women born before 1980 had a greater probability of maternal death in relation to recent generations, which is a reflection of the improvement in social determinants and in the Health System. The age effect shows a problem in maternal mortality in women under 15 years old, so teen pregnancy is a priority in health and must be addressed in short term. There is no clear evidence of a period effect.

INTRODUCTION: Two major technological paradigms have been developed in recent years, digital twins and the multiparadigm simulation. In the Health Sector, the enormous potential of both approaches for the management of public health emergencies is envisioned.OBJECTIVES: This study aims to develop the conceptual framework for the development of a Digital Public Health Emergency System. METHODS: The integration of the digital twins in health with the multi-paradigm simulation for the design of a digital system of public health emergencies is proposed. RESULTS:The proposal establishes the conceptual framework for the integration of a digital public health emergency system, incorporating multi-paradigm simulation in the construction of a digital twin.CONCLUSION: The use of cutting-edge technologies for public health emergencies will allow for a better response to contingencies as well as optimally managing the resources available in a health system.