Systemic lupus erythematosus often presents with involvement of the gastrointestinal tract of several causes. The lupus mesenteric vasculitis, a well-described entity, is rare, affecting between 1-2% of patients with lupus and abdominal pain, leading to severe and potentially fatal disease. We report a case of a young woman, without prior diagnosis, presenting with severe abdominal pain and fever with final diagnosis of lupus mesenteric vasculitis successfully treated with immunosuppression .We present a brief review of literature.
Acquired hemophilia is a bleeding disorder caused by the development of autoantibodies against plasma coagulation factors, most frequently against the factor VIII, or type A. We report a case of a 69-year-old patient with rheumatoid arthritis for 6 years with ecchymoses, hematomas and macroscopic hematuria, diagnosed with acquired hemophilia A secondary to rheumatoid arthritis, treated with methylprednisolone, desmopressin, activated prothrombin complex concentrate and cyclophosphamide, with remission.
BACKGROUNDTumor necrosis factor alpha (TNF-α) is a pro-inflammatory cytokine implicated in the pathogenesis of several autoimmune and rheumatic diseases. Tumor necrosis factor alpha antagonists were developed more than a decade ago and have shown increasing success in controlling chronic inflammatory diseases. However, blocking the physiological effect of TNF-α has led to adverse effects in some patients, with adalimumab, etanercept, and infliximab being the most implicated in the drug-induced lupus syndrome.
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