their ability to induce ataxia, to decrease locomotor activity, and to afford protection against electroshockand strychnine-induced convulsions in mice. In general, the compounds described herein failed to afford protection at an acceptable dose (<50 mg/kg) against convulsions induced by either method. However, many compounds induced ataxia, as judged by impairment of ability to traverse a suspended rod, and decreased motor activity. The data for the more interesting compounds are summarized in Table I; comparable data for Mannich base 1 are included.
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