Background. Pregnancy has disease-modifying effects in MS. First trimester abortion might be followed by increased MS activity. MS with myelin oligodendrocyte glycoprotein (MOG) autoantibodies is a rare and agressive disease variant. Objectives. This case illustrates severe inflammatory reactivation after surgical abortion in MS patient who carries MOG antibodies. Methods. Case-report. Patient provided written informed consent for information and images to be published. Results. MRI and CSF biomarkers indicated high inflammatory activity post-abortion. Conclusions. Pregnancy termination in combination with MOG antibody carriership and termination of dimethyl fumarate treatment just prior abortion have had contributed to extensive reactivation of MS.

Background. Pregnancy has disease-modifying effects in MS. First trimester abortion might be followed by increased MS activity. MS with myelin oligodendrocyte glycoprotein (MOG) autoantibodies is a rare and agressive disease variant.Objectives. This case illustrates severe inflammatory reactivation after surgical abortion in MS patient who carries MOG antibodies.Methods. Case-report. Patient provided written informed consent for information and images to be published. Results. MRI and CSF biomarkers indicated high inflammatory activity post-abortion. Conclusions. Pregnancy termination in combination with MOG antibody carriership and termination of dimethyl fumarate treatment just prior abortion have had contributed to extensive reactivation of MS.