Background:Bisphosphonate-related osteonecrosis of the jaws (BRONJ) is a well-known challenging entity warranting management. Platelet-Rich Plasma (PRP) plays an important role in bone biology by enhancing bone repair and regeneration.Objectives:The aim of this animal study was to evaluate the effects of PRP on zoledronic acid-induced BRONJ.Materials and Methods:Seven rats were given 0.04 mg Zoledronic acid intravenously once a week for five weeks. Two weeks later, the animals underwent extraction of their first lower molars, bilaterally. After clinical confirmation of the osteonecrosis, PRP was injected randomly into one of the extraction sockets of each rat. Three weeks later, all rats were sacrificed in order to obtain histological sections. The analysis of epithelialization was performed by McNamar’s test, and the analysis of osteogenesis and angiogenesis was performed by the Wilcoxon Sign Rank test. P value was set at 0.05.Results:We found no significant differences between the two groups regarding the amount of epithelialization, angiogenesis or sequestrum formation (P > 0.05), but a significant difference was seen between the two groups regarding the amount of existing vital bone (P < 0.05).Conclusions:Our study demonstrates positive results (preservation or regeneration of bone) using PRP in treatment of BRONJ. Although PRP may enhance osseous regeneration, long-term follow-ups are required to confirm its benefits.

Akhlaghi NM, Kahali R, Abtahi A, Tabatabaee S, Mehrvarzfar P, Parirokh M. Comparison of dentine removal using V-taper and K-Flexofile instruments.Aim To compare the dentine removal ability of VTaper and K-Flexofile instruments in mesiobuccal canals of extracted mandibular first molar teeth. Methodology Preoperative images of 40 mesiobuccal canals of mandibular first molars (with a curvature between 20°and 35°) were obtained at 2, 4.5, and 7 mm from the root apices by CT-scan and divided into two groups. Group F was prepared with K-Flexofiles and Gates Glidden drills and Group V with V-Taper Ni-Ti rotary and stainless steel hand instruments. Post-instrumentation images were then obtained and compared with the preoperative images. The ratio of dentine removal based on pre-and postoperative images was calculated, and data was analysed by anova and Tukey post hoc test. Results In group F in the coronal sections, the least ratio of the dentine removal to the initial root thickness was on the buccal aspect (15.14% ± 6.72), and the greatest ratio was found on the distolingual (29.38% ± 8.19). In group V in the coronal, the least ratio of the dentine removal to the initial root thickness was on the buccal aspect (9.81% ± 3.26); the greatest ratio was found on the distolingual surface in the coronal sections (34.38% ± 10.51). In the middle sections, the least ratio was on the buccal (10.51% ± 3.39) and the greatest on the distolingual aspects (27.46% ± 12.34) of the roots. In the apical sections, the amount of the dentine removed from the mesial and distal surfaces in group V was significantly more than group F (P < 0.01). Conclusion The distolingual aspect of the root canal is a danger zone for the mesiobuccal canal of the mesial root in mandibular molar teeth, and preparation of that area should be performed with caution. Except the apical part of the canal, no significant difference was found between the two preparation files or techniques used. Apart from the apical part of the canal, neither instrument maintained the original shape of the coronal and middle parts of the canal.

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