Periodontitis is a chronic infectious disease that is highly prevalent worldwide and is characterized by inflammation of the gums, and loss of connective tissue and bone support. The Gramnegative anerobic bacterium Porphyromonas gingivalis is generally accepted as the main etiological agent for chronic periodontitis. The objective of this paper is to elucidate the feasibility of achieving protection against periodontitis though immunization against P. gingivalis. Until now, animal studies have showed no complete protection against P. gingivalis. However, current knowledge about P. gingivalis structures could be applicable for further research to develop a successful licensed vaccine and alternative therapeutic strategies. This review reveals that a multicomponent vaccine against P. gingivalis, which includes structures shared among P. gingivalis serotypes, will be feasible to induce broad and complete protection. Keywords: capsule • fimbriae • gingipain • immunization • periodontitis • Porphyromonas gingivalis • vaccineFeasibility and therapeutic strategies of vaccines against Porphyromonas gingivalis Expert Rev. Vaccines 9(2), 193-208 (2010) For reprint orders, please contact reprints@expert-reviews.com Expert Rev. Vaccines 9(2), (2010)