The purpose of this study is gain a better understanding of the anatomical variations of celiac artery and its branches in dogs.The celiac artery supply was analyzed in thirty dogs.The animals were injected with solution of Petrolatex S65 and dissected to evidence the celiac artery origin and its proximal ramifications. The celiac artery and its proximal branches were dissected and lengthen.The celiac artery more frequently emerged ahead of the first lumbar vertebra in one way form. The medium length of the celiac artery was of 0.98 cm. The gastrolienal trunk was the predominant morphological arrangement with medium length of 0.19 cm. The lienal artery emerged in one way form emitting more frequently 2 main branches. A branch emerging of the celiac artery irrigating the left adrenal occurred in 4 animals. The left gastric artery presented 1 branch in 17 animals (56.7%), 2 branches in 11 animals (36.6%) and 3 branches in 3 animals (10%). The left pancreatic lobe received a main branch from the lienal artery in 24 animals (80.0%), two branches in 4 animals (13.4%), and a branch emerging of the gastrolienal trunk in 2 animals (6.6%).The present data should therefore provide important information for devising experiments and interpreting results when using the mongred dogs as a model for experimental surgery and radiolocal practice of the celiac artery specially when making comparisons to human anatomy.

Introduction: The relationship between cancer and thromboembolic events has been known for a long time. Lung and venous thromboembolism are frequent complications of lung cancer and its treatment, being a great cause of morbidity and mortality. We pretend to establish the relationship between lung and venous thromboembolism and lung cancer, describe patient characteristics and analyze the impact in the survival and prognosis.Material and Methods: It was a retrospective study. All research subjects were selected from lung cancer patients with a newly diagnosed lung and venous thromboembolism event admitted to Hospital S. João, between January 2008 and December 2013 and were followed until December 2014. Statistical analysis was performed with SPSS.Results: From the search, we obtained 113 patients. The majority was male, smokers or ex-smokers, and adenocarcinoma was the most frequent histologic type, being diagnosed mostly in advanced stages. We noticed that the median time between lung cancer diagnosis and lung venous thromboembolism was 2.9 months. In 24 patients (21.4%), the lung cancer diagnosis occurred after the lung and venous thromboembolism event and in 86 patients (76.8%), it occurred before the event. After a median follow up of 1.4 months, 107 (94.7%) patients died, 1 (0.9%) was lost to follow-up and 5 (4.4%) were still alive. The median survival rate was 1.5 months.Discussion: The diagnosis of lung and venous thromboembolism in patients with lung cancer is associated with bad prognosis. It occurs most frequently in patients with advanced disease, in the first months after lung cancer diagnosis and after beginning chemotherapy.Conclusion: Disease progression is an independent predictor with negative impact in overall survival.

Castleman disease is an uncommon and heterogenous lymphoproliferative disorder which is classified as unicentric or multicentric depending on the number of lymph nodes involved. Each type has a different clinical presentation, aetiology, treatment and prognosis. We report the case of a young woman who presented with cervical lymphadenopathy and a retroperitoneal mass, and was diagnosed with unicentric Castleman disease and pheochromocytoma. We describe the diagnostic steps, the complications that developed, and the importance of the differential diagnosis in the evaluation of these patients.

Tuberous sclerosis complex (TSC) is a rare, autosomal dominant disorder with a recognized phenotypic variability with clinical manifestations developing continuously throughout life. The follow-up of TSC patients is challenging. The authors present a case with a definite diagnosis of TSC with known skin, renal, hepatic and neuropsychiatric involvement, whose diagnosis of TSC-associated lymphangioleiomyomatosis was establish at a late stage after the patient had presented with recurrent pneumothorax. Notwithstanding, mammalian target of rapamycin inhibition therapy was initiated. LEARNING POINTS • Tuberous sclerosis complex (TSC) is a systemic and progressive disorder leading to significant morbidity, highlighting the need to closely monitor such patients. • TSC-associated lymphangioleiomyomatosis is the major pulmonary manifestation and screening at an early stage is imperative. • Managing TSC requires a multidisciplinary approach and the introduction of mammalian target of rapamycin (mTOR) inhibition therapy reinforces the need for collaboration between well-prepared health professionals.

Several studies proven the association between PIM and PPO with adverse pharmacological effects, hospitalizations, morbidity and mortality, functional disability and consequently associated with more costs 6,7 . Hence it is important to determine whether there are significant differences in the number and type of PIM and PPO according to the provenance of the patients. This study has as main objective to evaluate the differences between the provenances of the elderly that were hospitalized in the Internal Medicine Service and how the origin influences the basal state of health, the hospitalization and the evolution after discharge. MATERIAL AND METHODSA retrospective observational study was performed to evaluate the differences in health status according to the origin of the patients. The research protocol was approved by the Ethics Committee of the Unidade Local de Saúde do Alto Minho (ULSAM). Taking into account the 2011 census, the district of Viana do Castelo consists of 56,851 elderly people, 2 for a 95% confidence interval (calculated by Epiinfo®, version 7.2.1.0), the representative sample of the population of Viana includes 254 elderly people. Patients aged 65 or over who were admitted to the Internal Medicine Unit of ULSAM since January 1, 2019 to a total of 254 consecutive patients hospitalized in the beds under the responsibility of the authors, and hospitalization through the emergency service occurs randomly by the service. Patients in palliative care and in-hospital deaths were excluded because it was not possible to evaluate the PPO introduced, PIM suspended, rehospitalization and death within 6 months after discharge.