3-Methoxy-8.14-seco-l.3.5( 10).9-ostratetraen-l4.17-dion (l), ein Zwischenprodukt zur Darstellung von racem. &tradiol-3-methylather, wurde mikrobiologisch zum optisch aktiven 14cr-ol-17-on (3) bzw. 17/3-ol-14-on (6) reduziert. Diese Substanzen ermoglichen die Totaisynthese von optisch aktiven Ostranderivaten ohne Racemattrennung.
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