Major challenges in the design of oral dosage forms are their low solubility and low bioavailability. Improving the dissolution of these oral dosage forms are one of the most challenging tasks for the formulation scientists as most of the drug candidates are highly lipophilic in nature. Telmisartan and Ezetimibe belongs to the BCS class II, having high lipophilicity, poor water solubility and poor dissolution. The objective of this work was to improve the dissolution rate of poorly water soluble drugs by using porous carrier drug delivery system. Templating based spray drying methodology was used to prepare porous mannitol. Drug (Telmisartan, Ezetimibe) loaded porous mannitol carriers then characterized by P-XRD, DSC, SEM, BET surface area analysis and ATR-FTIR. ATR-FTIR studies showed complete removal of templating agent from carrier. P-XRD and DSC studies confirmed nano- confinement of drug in crystalline form. In vitro dissolution study results indicated that porous mannitol prepared using tartaric acid as templating agent showed significant improvement in dissolution rate than pure drugs and respective physical mixtures .These results suggest that, these porous carriers can be useful as drug carriers for improving the dissolution of lipophilic drugs. Keywords: Templating agent, Spray drying, Mannitol, Surface area, Tartaric acid.

Novel Coronavirus Disease 2019 (nCOV 2019) or Coronavirus is one which is associate communicable disease amongst variety of viruses that causes cold, fever, difficulty in breathing and ultimately death. The viruses cause metabolism infections, together with the mundane cold, that square measure usually delicate, although a lot of occasional forms like respiratory illness caused by SARS-CoV-2, the illness is that the reason for the 2019–20 coronavirus irruption. It’s primarily unfolded between individuals by diminutive droplets from infected people once they breathe or cough. Individuals could have few symptoms or develop febrility, cough, and shortness of breath. Whereas Feb 2020, different countries together with European country Asian Countries enclosed within the list. Antiviral drugs being tested embrace antimalarial drug, the ribonucleic acid enzyme substance remdesivir, and triazavirin, Umifenovir (Arbidol) and darunavir were planned. Remdesivir and antimalarial drug effectively inhibit the coronavirus in vitro. Favilavir approved as experimental corona virus drug. The objective of this review article to provide basic knowledge & preliminary opinion and to provide an advice which can be proved as the best mantra for defeating nCOV. Thus this review aims to throw light to the new and exciting areas of Virology,  Replication  cycle of corona virus ,  sign & symptoms and diagnosis, Spreading of corona virus, Structural biology of corona virus, the ways of treatment with  alternative medicines  other than antiviral drugs,  and prevention in its early stage of COVID-19 , and also Current Research on Corona. Keywords: Coronavirus, 2019-nCOV2, 2019–20 coronavirus irruption, SARS, WHO, Public Health Emergency of International Concern (PHEIC), replication of corona virus.

narrow therapeutic index in gastro intestinal track [3]. Long acting hormonal contraceptives depot formulations are the method of birth control that provides effective contraceptive action for longer period of time. Hormonal contraceptives advance the practice of contraception where injectable and subdermal routes of administration are used. When oral contraceptive shows the difficulty of maintaining daily intake of medicines, then there is need of long acting hormonal contraceptives method. Long acting hormonal contraceptive formulations taken every two to three month and solve the problem of daily intake of medicine. The development of long-acting steroidal contraceptive systems this is believed to be an important solution to the problems of effectiveness, safety, and acceptability of steroidal contraceptives, especially in developing countries [4].