Mycetoma is a chronic-granulomatous disease characterized by the inflammation, swollen organ, draining sinuses containing blood, pus, and grains. We present a case of madura foot with novel etiologic agent Madurella pseudomycetomatis. Diagnosis was based on morphologic, physiologic, histipathologic and molecular methods. In vitro antifungal susceptibility tests revealed that MIC values for itraconazole, amphotericin B, and posaconazole were 0.0313 μg/ml, 0.0313 μg/ml, and 0.004 μg/ml, respectively. The patient was treated and recovered by itraconazole(400 mg/day) after prolonged course.

The skin is the body's largest organ that hosts heterogeneous inhabitants. Until now, the diversity of the cutaneous microbiome was mainly investigated for bacteria and there is a little information about the skin fungal flora and Trichosporon is occasionally found as normal flora of skin. In this study, differences in Trichosporon community structure associated with 9 different skin sites of 238 healthy people during 10 months from July to March 2016, are described. These subjects were divided by age into 4 groups: infants, children, adults and geriatrics. The collected samples were examined by culture on Sabouraud Chloramphenicol Agar and Sabouraud Cycloheximide Chloramphenicol Agar. For precise identification of isolates in the species level, ITS1-5. 8S-ITS2 r DNA regions were sequenced. The frequency of Trichosporon species was not significantly different between age groups. The most Trichosporon isolations were related to the adult age group and the fewest in the infants. T.asahii was the predominant isolated species in all age groups. This study showed statistically significant effect of the subjects' sex on Trichosporon population resident on human skin surface.