Summary: Tablets containing 50,ug. of thyroxine and 15,ug. of triiodothyronine have been used to treat patients with hypothyroidism of varied aetiology. Following total thyroidectomy a daily dose of three tabletsthat is, 150,ig. of thyroxine and 45,ug. of triiodothyronine -maintained patients in a euthyroid state and produced a protein-bound iodine level within the normal range. The preparation is preferable to dried thyroid because of uniformity of activity and speed of action, and when the patient is clinically euthyroid the P.B.I. fails within the normal range.

The hypocalcasmia seen after thyroid surgery is almost certainly caused by several factors. These experiments were designed to demonstrate the patterns of postoperative hypocalcemia seen due to endogenous calcitonin release, and partial and complete parathyroidectomy. The rat with autotransplanted parathyroid glands was used as the experimental model

L-asparaginase (140,000 units) infused into the hepatic artery resulted in a remission from disabling hypoglycaemia for nine months in a man with islet cell carcinoma of the pancreas and hepatic metastases. The tumour produced insulin and gastrin with resulting hypoglycaemia and recurrent peptic ulceration which were unresponsive to other drugs. Following L-asparaginase there was a fall in both plasma and insulin and gastrin.